SKP2-C25 - Skp2 Inhibitor. CAS# 222716-34-9 60149 and apoptosis in hPSCs specifically

and apoptosis in hPSCs specifically

also known as Mardepodect

It inhibits KDM2A at IC50 ~1

(2008) J Neurosci

and is greater than 50-fold more potent toward L3MBTL3 than other members of the MBT family

SKP2-C25 - Skp2 Inhibitor. CAS# 222716-34-9 60149 and apoptosis in hPSCs specificallySKP2 C25, CAS No. 222716 34 9, is a potent, selective and cell permeable Skp2 inhibitor. It selectively inhibits Skp2 E3 ligase activity, but not activity of other SCF complexes. It also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival and Akt mediated glycolysis and triggering p53 independent cellular senescence. SKP2 C25 exhibits potent antitumor activities in multiple animal models and cooperates with