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InChiKey: OFCNXPDARWKPPY-UHFFFAOYSA-N
1-2H3/b10-6+
NVS-SM1 works by increasing the amount of functional SMN protein produced by the “back-up” gene
CC(C)CCOC(=O)C(CC(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)COC1=CC=C2C=CC=CC2=C1C1C(=CC=C2C=CC=CC2=1)OCCC(C)C
leading to the inhibition of the JAK/STAT (signal transducer and activator of transcription) signaling including activation of STAT3
TG003 oripenem monohydrate InChiKey: OFCNXPDARWKPPY-UHFFFAOYSA-NTG003 is a potent, ATP competitive inhibitor of Clk family kinases (IC50 values are 20, 200 and 15 nM for mClk1, 2 and 4 respectively and >10 M for mClk3). . TG003 inhibited SF2 ASF dependent splicing of beta globin pre mRNA in vitro by suppression of Clk mediated phosphorylation. TG003 also suppressed serine arginine rich protein phosphorylation, dissociation of nuclear speckles, and Clk1 Sty dependent alternative splicing in mammalian cells.