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acting as an androgen receptor degrader
It facilitates extinction and prevents reinstatement of cocaine-conditioned place preference
Genes Brain Behav
Molecular Weight: 368
PubMed PMID: 26259519
Ispinesib (SB-715992) st N-oxide acting as an androgen receptorIspinesib is a synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be