Bedaquiline Catalog No.:M8161-2 Smiles: COC1=CC=CC=C1C(=O)NC1=CC2=C(C=C1N1CCCC1)N(C)C(=O)N2C

Smiles: COC1=CC=CC=C1C(=O)NC1=CC2=C(C=C1N1CCCC1)N(C)C(=O)N2C

inhibited PI3K γ and -δ(IC50 values of 83 and 235 nM

InChiKey: ZCOLJUOHXJRHDI-CMWLGVBASA-N

Euglycemic human islet transplantation model and diabetic marginal mass human islet transplantation model

Smiles: CC1N=C(SC=1S(N)(=O)=O)N(C)C(=O)CC1=CC=C(C=C1)C1=CC=CC=N1

Bedaquiline Catalog No.:M8161-2 Smiles: COC1=CC=CC=C1C(=O)NC1=CC2=C(C=C1N1CCCC1)N(C)C(=O)N2CBedaquiline, also known as TMC207 and R207910, is a diarylquinoline anti tuberculosis drug, which was discovered by a team led by Koen Andries at Janssen Pharmaceutica. Bedaquiline blocks the proton pump for ATP synthase of mycobacteria. ATP production is required for cellular energy production and its loss leads to cell death, even in dormant or nonreplicating mycobacteria. It is the first member of a new class of drugs called the diarylquinolines.