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(2006) Proc Amer Assoc Cancer Res
(1991) Science
Smurf2 and WWP1 with IC50 6
Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis
poly(ADP)ribose polymerase cleavage
L002 (NSC764414) - p300 Inhibitor. CAS# 321695-57-2 Catalog No.:M60198-10S (2006) Proc Amer Assoc CancerL002 (NSC764414), CAS No. 321695 57 2, is a novel selective, cell permeable and reversible inhibitor of p300 histone acetyl transferase (IC50 ~1. 98 M). It has no activity in histone methyltransferases tested, including DOT1, EZH1, G9a, PRMT1, SETD2, SET7 9, SMYD2, and SUV39H2 etc. L002 was shown to occupy Ac CoA binding pocket of p300, and is less potent to CBP, PCAF, GCN5 and GNAT. It suppresses Histone H3 and H4 acetylation in triple negative
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