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2(6):408-18
InChi: InChI=1S/C19H17F6N7O/c1-17(2
CAS Number: 1621175-65-2
Salovska B
InChi: InChI=1S/C17H18BrN3O4S/c1-10-7-11(18)5-6-16(10)26(23
JIB-04 (NSC693627) - Jumonji Histone Demethylase Inhibitor. CAS# 199596-05-9 0156 2(6):408-18JIB 04 (NSC693627, E isomer), CAS No. 199596 05 9, is a potent, selective and cell permeable Jumonji histone demethylase inhibitor. Unlike the other known inhibitors, JIB 04 is not a competitive inhibitor of a ketoglutarate. It inhibits the demethylase activity of Jumonji enzymes in vitro, with IC50 ~230 nM for JARID1A (KDM5A), ~440 nM for JMJD2A (KDM4A) and JMJD2B (KDM4B), ~340 nM for JMJD2E (KDM2E), and ~1 M for JMJD3 (KDM6B) and JMJD2C (KDM4C). JIB
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