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and SW480 cancer cells with IC50 values of 0
18-dimethoxy-17-(3
including stimulation of Ca2+ mobilization
AK-7 treatment resulted in improved motor function
2002 Nov-Dec
VER-49009 Size:Solid 10 mg and SW480 cancer cells withVER 49009 is a potent HSP90 inhibitor. VER 49009 inhibits Hsp90 with an IC50 value of 47 nM. VER 49009 produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER 49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C RAF, B RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis. Product information CAS Number: 558640 51