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Smiles: CC1(C)O[C@@]2(C/C=C(/C)\C(O)=O)C(=O)[C@H]3C[C@@H]1[C@]12OC2=C(CC=C(C)C)C4O[C@@](C)(CCC=C(C)C)C=CC=4C(O)=C2C(=O)C1=C3
Homozygous KO and KI mice fed a Thiamine-restricted diet (thiamine: 0
The drug treatment led to tumor growth inhibition (TGI) of an EZH2 mutant KARPAS-422 DLBCL xenograft
CAS Number: 131189-57-6
0) and a low-affinity antagonist of D2 receptor (pKi=6
L-778123 hydrochloride Size:Contact [email protected] for quotation Smiles: CC1(C)O[C@@]2(C/C=C(/C)\C(O)=O)C(=O)[C@H]3C[C@@H]1[C@]12OC2=C(CC=C(C)C)C4O[C@@](C)(CCC=C(C)C)C=CC=4C(O)=C2C(=O)C1=C3L 778123 hydrochloride is an inhibitor of FPTase and GGPTase I with IC50 of 2 nM and 98 nM in enzyme inhibition determination. IC50 value: 2 nM Target: FPTasein vitro: L 778123 can completely inhibit Ki Ras prenylation. L 778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti cancer agent. in vivo: In the dog model, L 778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of