ALX-1393 27420 Ft1 enhanced the phosphorylation of

Ft1 enhanced the phosphorylation of ERK1/2

and improves functional recovery following status epilepticus (SE)

Selectivity over KDR can be rationalised predominantly by the interaction of water molecules with the protein and ligand in the active site and its kinome selectivity is similar to the best of the approved GIST agents

It increases the activity of pSer9-glycogen synthase kinase and insulin degrading enzyme (IDE) and reduces the accumulation of amyloid-β (1-42) (Aβ42) in the rat hippocampal CA1 and CA3 regions in a model of vascular dementia induced by chronic cerebral hypofusion

Formula: C28H31ClN2O2

ALX-1393 27420 Ft1 enhanced the phosphorylation ofALX 1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model. Product information CAS Number: 949164 09 4 Molecular Weight: 395. 42 Formula: C23H22FNO4 Chemical Name: (2S) 2 amino 3 {[2 (benzyloxy)phenyl](3 fluorophenyl)methoxy}propanoic acid Smiles: N[C@@H](COC(C1=CC=CC=C1OCC1C=CC=CC=1)C1=CC(F)=CC=C1)C(O)=O InChiKey: ADUSZEGHFWRTQS AIBWNMTMSA N InChi: InChI=1S