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inhibitor of the F0 part of H+-ATP-synthase
2R)-2-[(cyclopropylmethyl)amino]cyclopropyl]phenyl}-1-methyl-1H-pyrazole-4-carboxamide hydrochloride
Formula: C77H96ClF3N10O10S4
Formula: C17H16N4O
CD38-IN-78c
Tankyrase Inhibitors (TNKS) 22 halin inhibitor of the F0 partTankyrase Inhibitors (TNKS) 22 is a potent, selective and orally bioavailable inhibitor of tankyrase with IC50 value of 0. 1nM . Tankyrase 1 and tankyrase 2 are members of PARP family. They can use NAD+ as substrates to transfer ADP ribose polymers onto tagert proteins. The tankyrase are found to bind to PARSylate axin proteins which are the negative regulator of Wnt pathway. It makes tankyrase to be targets in treatment for adenomatous polyposis