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K/c20-15(21)7-8-18-16(22)14(27-17(18)26)9-12-5-6-13(25-12)10-1-3-11(4-2-10)19(23)24
flow cytometric analysis is used to detect the cell apoptosis both in SW620 cells and Cisp-resistant SW620 cells
Chemical Name: 6-(2-(tert-butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline
Simpson PB
Sephin1 was used at 0
GRP-60367 - CAS# 1309241-34-6 size:10mg solid K/c20-15(21)7-8-18-16(22)14(27-17(18)26)9-12-5-6-13(25-12)10-1-3-11(4-2-10)19(23)24GRP 60367, CAS No. 1309241 34 6, is a potent and selective rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP 60367 inhibits entry of a subset of RABV strains. Resistance profiling of the chemotype revealed hot spots in conserved hydrophobic positions of the RABV G protein fusion loop that were confirmed in transient cell to cell fusion assays. Transfer of RABV G genes with signature resistance mutations into a