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11aH-cyclopenta[a]phenanthren-1-yl]ethan-1-one
PHOtochemically TArgeting Chimera)
Formula: C17H13NO2
InChi: InChI=1S/C19H17F6N7O/c1-17(2
InChi: InChI=1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11
Topotecan Hydrochloride Size:Solid 2 mg 11aH-cyclopenta[a]phenanthren-1-yl]ethan-1-oneTopocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I DNA covalent complexes, inhibiting religation of topoisomerase I mediated single strand DNA breaks and producing potentially lethal double strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline based alkaloid
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