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InChiKey: DOEWDSDBFRHVAP-KRXBUXKQSA-N
Erk1/2- and Stat3 activity in both cell lines
GPR39-C3 was used at 0
or IP dosed at 25 mg/kg once a day on a 5-on
1-a]isoindol-5-yl)ethan-1-ol
AG-120 (Ivosidenib) - IDH1 Inhibitor. CAS# 1448347-49-6 Catalog No.:M60318-10S InChiKey: DOEWDSDBFRHVAP-KRXBUXKQSA-NAG 120 (Ivosidenib), CAS No. 1448347 49 6, is a potent, selective and reversible inhibitor of IDH1 with IC50 < 100 nM. It has been shown to lower 2 HG levels and restore cellular differentiation in IDH1 mutant primary human blast cells cultured ex vivo. In phase I clinical trials targeting patients with IDH1 mutated, relapsed and or refractory (R R) AML or untreated AML not eligible for standard of care or R R MDS, AG 120 is well tolerated to date (10