Sorafenib Tosylate - CAS# 475207-59-1 rizine dihydrochloride with IC50 and KD values

with IC50 and KD values close to or below 1 nM as well as a slow dissociation rate

ClH/c1-13-16-11-14(21)3-6-19(16)28-20(13)29(25

2095432-75-8

caused by either genetic or small-molecule inhibition of G9a

Formula: C35H49N11O9S2

Sorafenib Tosylate - CAS# 475207-59-1 rizine dihydrochloride with IC50 and KD valuesSorafenib, also known as BAY 43 9006, is a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF MEK ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR 2 PDGFR beta signaling cascade, thereby blocking tumor angiogenesis. Sorafenib was approved in 2005 for use in the treatment of advanced renal cancer. Product