PF-3450074 60276 Smiles: CCC(C)C(NC(=O)C(CC1C=CC(O)=CC=1)NC(=O)C(N)CCCCN)C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CC(N)=O)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(O)=O

Smiles: CCC(C)C(NC(=O)C(CC1C=CC(O)=CC=1)NC(=O)C(N)CCCCN)C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CC(N)=O)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(O)=O

) alleviates D-GalN induced hepatotoxicity in mice

InChi: InChI=1S/C51H103NO26/c52-2-4-56-6-8-58-10-12-60-14-16-62-18-20-64-22-24-66-26-28-68-30-32-70-34-36-72-38-40-74-42-44-76-46-48-78-50-49-77-47-45-75-43-41-73-39-37-71-35-33-69-31-29-67-27-25-65-23-21-63-19-17-61-15-13-59-11-9-57-7-5-55-3-1-51(53)54/h1-50

it against Plasmodium falciparum and E

CC(C)C1=C(C(=C(C2C=CC(F)=CC=2)N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1C=CC=CC=1)C(=O)NC1C=CC=CC=1

PF-3450074 60276 Smiles: CCC(C)C(NC(=O)C(CC1C=CC(O)=CC=1)NC(=O)C(N)CCCCN)C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CC(N)=O)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(O)=OPF 3450074 (PF 74) is a specifical inhibitor of HIV 1 capsid protein (CA) and displays a broad spectrum inhibition of HIV isolates with submicromolar potency (EC50=8 640 nM). PF 3450074 (PF 74) acts at an early stage of HIV 1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. CPSF6: nuclear host factors