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InChi: InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H
Janeta Popovici-Muller
In GDC-0879 treated mice
31(8):837-60
CAS Number: 55981-09-4
TAK-779 Catalog No.:M10030-10 InChi: InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1HTAK 779 is a C C chemokine receptor type 5 (CCR5) receptor antagonist potentially for the treatment of HIV infection. Treatment with TAK 779 reduced incidence and severity of experimental autoimmune encephalomyelitis. It strongly inhibited migration of CXCR3 CCR5 bearing CD4+, CD8+ and CD11b+ leukocytes to the CNS. TAK 779 did not reduce proliferation of anti myelin oligodendrocyte glycoprotein T cells, the production of IFN gamma by T cells or CXCR3
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