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Preclinical studies reveal that KW-2449 is converted by monoamine oxidase-B (MAO-B) and aldehyde oxidase into its major metabolite M1
CN1C2NC=NC=2C(=O)N(C)C1=O
42-dodecamethyl-15
Brassinolide
Afuresertib HCl
Vortioxetine hydrobromide troban Preclinical studies reveal that KW-2449Vortioxetine, also known as Lu AA21004, is an atypical antidepressant, and was approved in 2013 by the U. S. FDA for the treatment of major depressive disorder (MDD) in adults. Vortioxetine is a so called "serotonin modulator and stimulator." It has been shown to possess the following pharmacological actions: Serotonin transporter (SERT) blocker (i. e. serotonin reuptake inhibitor (SRI)) Ki (binding affinity) = 1. 6 nM, IC50 = 5. 4 nM; Norepinephrine
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