NGB 2904 hydrochloride nedioic Acid NC1NC(=O)C2N=CN([C@H]3C[C@H](O)[C@@H](CO)O3)C=2N=1

NC1NC(=O)C2N=CN([C@H]3C[C@H](O)[C@@H](CO)O3)C=2N=1

InChi: InChI=1S/C53H84NO14P/c1-32-18-14-13-15-19-33(2)44(63-8)30-40-23-21-38(7)53(61

InChiKey: OXSCPDKUZWPWFR-UHFFFAOYSA-N

AGN-201904-Z is the sodium salt

using IDO-expressing mouse DCs from tumor-draining lymph nodes

NGB 2904 hydrochloride nedioic Acid NC1NC(=O)C2N=CN([C@H]3C[C@H](O)[C@@H](CO)O3)C=2N=1NGB 2904 hydrochloride is a potent, selective, orally active and brain penetrated antagonist of dopamine D3 receptor, with a Ki of 1. 4 nM. NGB 2904 hydrochloride shows selectivity for D3 over D2, 5 HT2, 1, D4, D1 and D5 receptors (Kis=217, 223, 642, >5000, >10000 and >10000 nM, respectively). NGB 2904 hydrochloride antagonizes Quinpirole stimulated mitogenesis. NGB 2904 hydrochloride can inhibit Cocaine's rewarding effects and Cocaine induced