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selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family protein BRD4 with an IC50 of ~35 nM
MLN8237 was dosed to mice orally at 15-30 mg/kg once per day
Solubility: DMSO: ≥ 33 mg/mL
182004-65-5
SAR407899 (1
AAE-581 - CAS# 354813-19-7 60167 selective and cell permeable inhibitorBalicatib(AAE 581), CAS No. 354813 19 7, is a potent and selective inhibitor of cathepsin K; 10 100 fold more potent in cell based enzyme occupancy assays than against cathepsin B, L, and S. IC50 value: Target: cathepsin K The cathepsin K inhibitor AAE 581 (balicatib) as the most advanced of them passed Phase II clinical trials in 2005. Eighty adult female Macaca fascicularis underwent bilateral ovariectomies and were dosed twice daily by oral gavage
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