CB-5083 - p97 AAA ATPase Inhibitor. CAS# 1542705-92-9 0187 Smiles: CC(C)NC1=NC(NC2C=CC=CC=2)=NC(=N1)C1C=CC=CC=1

Smiles: CC(C)NC1=NC(NC2C=CC=CC=2)=NC(=N1)C1C=CC=CC=1

000-fold selectivity against all PI3K isoforms (α

by acting downstream of eIF2α phosphorylation

Formula: C22H26N4O3

and prostate cancer (IC50 ~0

CB-5083 - p97 AAA ATPase Inhibitor. CAS# 1542705-92-9 0187 Smiles: CC(C)NC1=NC(NC2C=CC=CC=2)=NC(=N1)C1C=CC=CC=1CB 5083, CAS No. 1542705 92 9, is a novel first in class, potent orally bio available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti tumor activity in solid and hematological models . CB 5083 causes rapid and sustained accumulation of poly ubiquitin in tumor xenografts after a single administration. CB 5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB 5083 appears to