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2015 Apr 12
21)22)13(19)8-12(18-11)9-3-2-4-10(17)7-9
184(11):6529-36
VER155008 (25 mg/kg
CI994 was used at 2
ML-329 - CAS# 19992-50-8 Catalog No.:M6543-2 2015 Apr 12ML 329, CAS No. 19992 50 8, is an inhibitor of the microphthalmia associated transcription factor (MITF) pathway with an IC50 value of 1. 2 M for promoter activity of the MITF target gene TRPM 1. ML 329 showed specific activity against the MITF dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML 329 reduced the expression of multiple MITF target genes, including pigment related genes and the cell cycle regulator CDK2.
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