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In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002)
InChi: InChI=1S/C14H7ClFN3O5/c15-10-5-7(1-3-11(10)16)18-14(21)9(13(20)17-18)6-8-2-4-12(24-8)19(22)23/h1-6H
GNF4877 was orally dosed to mice at 50 mg/kg twice a day for 14 days
Fatostatin A was used at 10-20 µM in vitro
It can suppress proliferation
Rapamycin - mTOR inhibitor. CAS# 53123-88-9 size:2mg solid In vivo and in vitroRapamycin, CAS No. 53123 88 9, is a potent and selective mTOR inhibitor. Rapamycin, in complex with the cytosolic protein FK binding protein 12 (FKBP12), inhibits mTOR Complex 1 (mTORC1) by binding to the FRB domain of mTor. Given the central roles mTor plays, Rapamycin showed diverse activities, including anti proliferative effects in cancer cells, immunosuppressive effect, lifespan extension in mice, improved cognition in the mouse model of autism
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