Sofosbuvir impurity N lolactone Novobiocin binds to DNA gyrase

Novobiocin binds to DNA gyrase

1 In clinical trials

TH-302 exhibits potent cytotoxicity to both human and murine MM cells with hypoxic selectivity and dose dependency

InChiKey: IVUIPHKZPNUXGG-MRXNPFEDSA-N

81 nM and 116 nM for NIH 3T3

Sofosbuvir impurity N lolactone Novobiocin binds to DNA gyraseSofosbuvir impurity N, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI 7977) is an inhibitor of HCV RNA replication, demonstrates potent anti hepatitis C virus activity. Product information CAS Number: 1394157 34 6 Molecular Weight: 501. 40 Formula: C20H25FN3O9P Chemical Name: methyl (2S) 2 {[(S) {[(2R,3R,4R,5R) 5 (2,4 dioxo 1,2,3,4 tetrahydropyrimidin 1 yl) 4 fluoro 3 hydroxy 4 methyloxolan 2