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Treatment with a combination of enzastaurin and the GSK3 inhibitor AR-A014418 leads to increased levels of β-catenin total protein and β-catenin-mediated transcription
Formula: C21H22O11
CAS Number: 346640-08-2
40)25(37)18(13)23(35)19(15)22(14)34/h10
9)3(6)4(7)8/h3
N-Desethyl Sunitinib Size:Solid 10 mg Treatment with a combination ofN Desethyl Sunitinib is a metabolite of sunitinib. Sunitinib is a potent, ATP competitive VEGFR, PDGFR and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR 1, 2, 3, PDGFR and KIT, respectively. Sunitinib also potently inhibits Kit and FLT 3. Sunitinib inhibits VEGF induced proliferation of serum starved HUVECs with IC50 of 40 nM, and inhibits PDGF induced proliferation of NIH 3T3 cells overexpressing PDGFR or PDGFR with IC50 of 39 nM and
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