COTI-2 nositol Chemical Name: 4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1

Chemical Name:  4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1

Solubility: DMSO : 100 mg/mL (173

80-diisobutyl-11

and serotonergic receptors

with IC50 values of 79 μM and 2

COTI-2 nositol Chemical Name: 4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1COTI 2, an anti cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI 2 acts both by reactivating mutant p53 and inhibiting the PI3K AKT mTOR pathway. COTI 2 induces apoptosis in multiple human tumor cell lines. COTI 2 exhibits antitumor activity in HNSCC through p53 dependent and independent mechanisms. COTI 2 converts mutant p53 to wild type conformation. Product information CAS Number: 1039455 84