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42(5):1822-1836
and this effect was shown to be associated with reorganisation of ZO-1 to the cell periphery in Con8 mammary epithelial tumor cells
A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity
Formula: C26H29NO
1140964-99-3
ATP (disodium salt) quantel 42(5):1822-1836RO4987655, also known as CH4987655, is an orally active small molecule, targeting mitogen activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK inhibitor RO4987655 binds to and inhibits MEK, which may result in the inhibition of MEK dependent cell signaling and the inhibition of tumor cell proliferation. MEK, a dual specificity threonine tyrosine kinase, is a key component of the RAS RAF MEK ERK signaling
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