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Name: T-448 free base Size:Contact sales@xcessbio.com for quotation Smiles: CC1(C)[C@@H]2CC[C@]3(C)[C@H](C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)[C@@]2(C)CC[C@@H]1O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O)C(O)=O
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Smiles: CC1(C)[C@@H]2CC[C@]3(C)[C@H](C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)[C@@]2(C)CC[C@@H]1O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O)C(O)=O

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InChiKey: OPAWIOJQONUGQY-UHFFFAOYSA-N

Dabrafenib: a new opportunity for the treatment of BRAF V600-positive melanoma

130(7):1653-6

T-448 free base Size:Contact [email protected] for quotation Smiles: CC1(C)[C@@H]2CC[C@]3(C)[C@H](C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)[C@@]2(C)CC[C@@H]1O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O)C(O)=OT 448 free base is a specific, orally active and irreversible inhibitor of lysine specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T 448 free base enhances H3K4 methylation in primary cultured rat neurons. Product information CAS Number: 1597426 52 2 Molecular Weight: 328. 43 Formula: C17H20N4OS Chemical Name: 3 [(1S,2R) 2 (cyclobutylamino)cyclopropyl] N (5 methyl 1,3,4 thiadiazol 2 yl)benzamide Smiles:

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