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is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain
Molecular Weight: 289
Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design
Baselga JM
It has >100-fold selectivity over other methyltransferases and other non-epigenetic targets
5-Hydroxymethyldeoxyuridine - CAS# 5116-24-5 180 is a cell-permeable Stat3 inhibitor5 Hydroxymethyldeoxyuridine, CAS No. 5116 24 5, is a nucleoside analog with anticancer and antiviral activities. It inhibits the replication of murine S180 lung carcinoma cells and Ehrlich ascites mammary carcinoma cells (ED50s = 8. 5 and 4 M, respectively) and multiple human leukemia cell lines (IC50s = 1. 7 5. 8 M). Product information CAS Number: 5116 24 5 Molecular Weight: 258. 23 Formula: C10H14N2O6 Synonym: 5 Hydroxymethyl 2' deoxyuridine
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