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PubMed Central PMCID: PMC4146675
FGF401 binds to and inhibits the activity of FGFR4
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and tube formation
PF-8380 03-204 PubMed Central PMCID: PMC4146675PF 8380 is a potent autotaxin inhibitor with an IC(50) of 2. 8 nM in isolated enzyme assay and 101 nM in human whole blood. PF 8380 has adequate oral bioavailability and exposures required for in vivo testing of autotaxin inhibition. Autotaxin's role in producing LPA in plasma and at the site of inflammation was tested in a rat air pouch model. The specific inhibitor PF 8380 , dosed orally at 30 mg kg, provided >95% reduction in both plasma and air
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