KU-60019 B018304 and anchorage-independent colony formation in

and anchorage-independent colony formation in soft agar

as well as tumor angiogenesis

Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases

is the product of hydrolysis by acids

GSK3117391

KU-60019 B018304 and anchorage-independent colony formation inKU 60019 is a potent and selective ATM inhibitor. KU 60019 is 10 fold more effective than KU 55933 at blocking radiation induced phosphorylation of key ATM targets in human glioma cells. As expected, KU 60019 is a highly effective radiosensitizer of human glioma cells. KU 60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells