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PubMed PMID: 10762053
AZ5104 display minimal off-target activity against other non-HER family kinases
InChi: InChI=1S/C18H19F3N2O4S2
6-diphenyl-1
GSK-J4 was used at 30 µM final concentration in cellular assays
UF010 - HDAC Inhibitor. CAS# 537672-41-6 Catalog No.:M60278-2S PubMed PMID: 10762053UF 010, CAS No. 537672 41 6, is a Class I HDAC inhibitor (IC50 values are 0. 06, 0. 1, 0. 5 and 1. 5 M for HDACs 3, 2, 1 and 8, respectively). UF010 inhibits cancer cell proliferation via class I HDAC inhibition. This causes global changes in protein acetylation and gene expression, resulting in activation of tumor suppressor pathways and concurrent inhibition of several oncogenic pathways. The isotype selectivity coupled with interesting biological