β-Lapachone 099.1 amine-Boc hydrochloride PH-797804 reduces tumor growth of

PH-797804 reduces tumor growth of the three PDXs

1H3/b16-6-

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CAS Number: 633-65-8

Epub 2014 Jun 21

β-Lapachone 099.1 amine-Boc hydrochloride PH-797804 reduces tumor growth ofARQ 501, also known as beta lapachone, is a naphthoquinone compound derived from bark of Tabebuia sp., with antitumor, antibacterial, antifungal and antitrypanosomal activities. Beta lapachone exerts its anti tumor effect by indirect actions of inducing p53 independent apoptosis and cell cycle arrest mediated through altered activities of cell cycle control regulatory proteins; including down regulating retinoblastoma protein (pRB), a transcriptional