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Smiles: OC(=O)CCC1=C(NC2=CC(Cl)=CC(Cl)=C12)C(O)=O
Smiles: CN(C)C1C=CC(=CC=1)C(C1=CC(=CC=C1Cl)[N+]([O-])=O)C1C=CC(=CC=1)N(C)C
Formula: C4H3FN2O2
despite the lack of progress in achieving markedly higher solubility
Lauridsen JB
Regorafenib Catalog No.:M10913-10 Smiles: OC(=O)CCC1=C(NC2=CC(Cl)=CC(Cl)=C12)C(O)=ORegorafenib, also known as BAY 73 4506 ; is a n orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities. Regorafenib binds to and inhibits vascular endothelial growth factor receptors (VEGFRs) 2 and 3, and Ret, Kit, PDGFR and Raf kinases, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation. Regorafenib demonstrated to increase the overall survival of patients with metastatic
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