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CBP/EP300-IN-2
Chemical Name: 3-{[(1S
Smiles: O/N=C1/C(/NC2=CC=CC=C2/1)=C1\C(=O)NC2=CC=CC=C2\1
'rescuing' the patient while permitting the antitumor activity of the folate antagonist
Maximum inhibition (70 to 80%) is achieved at 1 μg/mL (3 μM)
AG-370 Catalog No.:M22560-C CBP/EP300-IN-2IC50: 20 M for PDGF receptor kinase in human bone marrow fibroblasts AG 370 is a tyrphostin PDGFR inhibitor. Protein tyrosine kinase inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of protein tyrosine kinases. Tyrphostins are a class of antiproliferative agents selectively inhibiting protein tyrosine kinases of key growth factors including epidermal growth factor or platelet derived growth factor (PDGF) via