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Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity
tolerability
UNC0379 was used at 10-30 µM in vitro assays
1418033-25-6
Formula: C17H15NO3
Ferrostatin-1 - Fer-1, Ferroptosis Inhibitor. CAS# 347174-05-4 size:2mg solid Enhanced activity of monomethylauristatin FFerrostatin 1 (Fer 1), CAS No. 347174 05 4 , is a potent inhibitor of ferroptosis with an EC50 ~60 nM, identified by a HTS using erastin induced ferroptosis in HT 1080 cells. Ferroptosis is a unique iron dependent form of nonapoptotic cell death triggered by the oncogenic RAS selective lethal small molecule erastin. Ferroptosis is dependent upon intracellular iron, but not other metals, and is morphologically, biochemically, and genetically distinct
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