CCG-63808 metabolite Hydroxy Iloperidone which binds with high affinity

which binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR)

[O-]C(=O)CCN1C(=O)/C(=C/C2=CC=C(O2)C2C=CC(=CC=2)[N+]([O-])=O)/SC1=S

14b-icosahydropicen-3-yl]oxy}-5-{[(2R

1-dimethylethyl ester

(2001) 14 226

CCG-63808 metabolite Hydroxy Iloperidone which binds with high affinityCCG 63808 is a potent and reversible RGS protein inhibitor. Regulators of G protein signalling (RGS) are major determinants of metabotropic receptor activity, reducing the lifespan of the GTP bound state of G proteins. Inhibition of spinal RGS4 restored endogenous analgesic signalling pathways and mitigated neuropathic pain. Signalling through CB1 receptors may be involved in this beneficial effect. Product information CAS Number: 620113 73 7