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XL888 was orally dosed to mice at 100 mg/kg 3 times a week in xenograft models
56124-62-0
Celecoxib reduces acute inflammation in the carrageenan edema assay with an ED50 of 7
Apixaban also shows small volume of distribution (Vdss: 0
Chemical Name: 2-((2-methylbutyl)amino)-1-(4-((m-tolyloxy)methyl)-3a
AG-120 - CAS# 1448346-63-1 164 XL888 was orally dosed toAG 120 (racemic), a racemic mixture of AG 120, CAS No. 1448346 63 1, is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Upon administration, AG 120 specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhibits the formation of the oncometabolite, 2 hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular