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24 hours) exhibits general cytostatic but type-specific cytotoxic effects for melanoma cells
Formula: C21H28N2O8S2
Smiles: CC1N=C(SC=1C(=O)NCC1C=NC=CC=1)N1CCN(CC2C=CC(F)=CC=2)C1=O
Armstrong KA
Administration of NCX-1000 to BDL and sham operated rats results in a similar increase of nitrite/nitrate and cGMP concentrations in the liver
CFI-400945 rexol 24 hours) exhibits general cytostaticCFI 400945 is an orally active, potent and selective inhibitor of polo like kinase 4. Polo like kinase 4 (PLK4), a unique member of the Polo like family of kinases, shares little homology with other polo like kinases. PLK4 plays an essential role in centriole duplication. Overexpression of PLK4 overrides the centriole licensing mechanism and results in centriole amplification with multiple procentrioles forming around each parental centriole.