(E/Z)-AG490 - CAS# 134036-52-5 CB 3284 8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioate

8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioate

∼50 and ∼50 nM for PARP1

Recent data has shown that GSK-J1 also shows some activity (IC50 950 nM for Jarid1b

identified by a cell-based Hh pathway reporter screening

31)/t23-/m0/s1

(E/Z)-AG490 - CAS# 134036-52-5 CB 3284 8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioate(E Z) AG490 ((E Z) Tyrphostin AG490) is a racemic compound of (E) AG490 and (Z) AG490 isomers. (E) AG490 (HY 12000) is a tyrosine kinase inhibitor that inhibits EGFR, Stat 3 and JAK2 3. Product information CAS Number: 134036 52 5 Molecular Weight: 294. 30 Formula: C17H14N2O3 Synonym: (E Z) Tyrphostin AG490 (E Z) Tyrphostin B42 Chemical Name: (E Z) N benzyl 2 cyano 3 (3, 4 dihydroxyphenyl)acrylamide Smiles: N#CC(=CC1=CC(O)=C(O)C=C1)C(=O)NCC1C=CC=CC=1