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Chemical Name: N-[(piperidin-2-yl)methyl]-2
InChi: InChI=1S/C33H29N3O5/c1-20-22(3)35(19-23-8-10-25(11-9-23)28-6-4-5-7-29(28)33(38)39)31-17-14-26(18-30(20)31)32(37)34-21(2)24-12-15-27(16-13-24)36(40)41/h4-18
InChi: InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13
Solubility: DMSO : ≥ 48 mg/mL (132
CAS Number: 85416-75-7
ZNL 02-096 Catalog No.:M11497-2 Chemical Name: N-[(piperidin-2-yl)methyl]-2ZNL 02 096 is a potent and selective Wee1 Degrader (PROTAC) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon binding ligand Pomalidomide (Cat. No. 6302). ZNL 02 096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT 4 cells in vitro, ZNL 02 096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2 M phase and apoptosis.