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When screened in a single point assay at 10 μM against a Cerep receptor and enzyme panel only one target is inhibited >50% (PDE3
including all isoforms of PI3K (less than 25% inhibition when tested at 1 μM against Invitrogen kinase panel)
Dual Inhibition of Activin/Nodal/TGF-β and BMP Signaling Pathways by SB431542 and Dorsomorphin Induces Neuronal Differentiation of Human Adipose Derived Stem Cells
for which there is at least a 400-fold selectivity versus FGFR1
TUG-770 (Compound 22
APTO-253 eptor Agonist When screened in a singleAPTO 253 (LOR 253, LT 253) inhibits c Myc expression and selectively induces CDKN1A (p21), promotes G0 G1 cell cycle arrest, and triggers apoptosis in acute myeloid leukemia (AML) cells. APTO 253 is also an inducer of KLF4 (Krppel like factor 4). Product information CAS Number: 916151 99 0 Molecular Weight: 367. 38 Formula: C22H14FN5 Chemical Name: 2 (5 fluoro 2 methyl 1H indol 3 yl) 1H imidazo[4,5 f][1,10]phenanthroline Smiles:
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