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Allele-specific p53 mutant reactivation
Smiles: CN(C)CC1=CC(=CC=C1)N/C(=C1/C2=CC=C(C=C2NC/1=O)C(N)=O)/C1C=CC=CC=1
The NHS ester can be used to label the primary amines (-NH2) of proteins
It targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor
Reprogramming of human primary somatic cells by OCT4 and chemical compounds
LDN-193189 - BMP inhibitor. CAS# 1062368-24-4 423 Allele-specific p53 mutant reactivationLDN 193189, CAS No. 1062368 24 4, is a cell permeable, highly potent and selective BMP pathway inhibitor by inhibiting BMP type I receptors ALK2 (IC50=5 nM) and ALK3 (IC50=30 nM), but not ALK4, ALK5, and ALK7 (> 0. 5 M). It prevents Smad1, Smad5, and Smad8 phosphorylation. It is a useful tool compound to modulate stem cell differentiation (for example, neural differentiation of human ESC iPSC in combination with SB431542). It was also used in animal
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