![AM095 (free acid) - CAS# 1228690-36-5 tate) COC1=C(CS(=O)C2[N-]C3=CC(=CC=C3N=2)OC(F)F)N=CC=C1OC](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/M10154_1621561416.gif?v=1742883124)
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COC1=C(CS(=O)C2[N-]C3=CC(=CC=C3N=2)OC(F)F)N=CC=C1OC
and the activity remains persistent
TG101348 induces apoptosis in both HEL and Ba/F3 JAK2V617F cells
and triggers mitochondrial dysfunction in MCs
currently approved for use in dogs and horses
AM095 (free acid) - CAS# 1228690-36-5 tate) COC1=C(CS(=O)C2[N-]C3=CC(=CC=C3N=2)OC(F)F)N=CC=C1OCAM095 is a potent LPA1 receptor antagonist because it inhibited GTPS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0. 98 and 0. 73 M, respectively, and exhibited no LPA1 agonism. Lysophosphatidic acid (LPA) is a bioactive phospholipid that signals through a family of at least six G protein coupled receptors designated LPA1 6. LPA type 1 receptor (LPA1) exhibits widespread
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