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Chemical Name: (S)-N-(4-((2S
pharmthera
1H-Indole-3-acetic acid
Smiles: C1C2=CC3OCOC=3C=C2OCN1CCOC12CC3CC(C1)CC(C2)C3
Formula: C24H26N6O3
(S)-Willardiine Catalog No.:M8448-2 Chemical Name: (S)-N-(4-((2S(S) Willardiine is a potent agonist of AMPA kainate receptors with EC50 of 44. 8 uM. IC50 value: 44. 8 uM(EC50) Target: AMPA kainate receptor agonistin vitro: The (S) but not (R) isomers of willardiine and 5 bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses . At a concentration of 1. 8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50% . in vivo: In newborn mice (P5,
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