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These results indicate CI-1040 exerts its effects on cells by suppressing the activation of MKK1
and the effect of GW501516 on ROS generation in BV-2 cells stimulated with LPS
PubMed PMID: 25533522
121569-61-7
InChi: InChI=1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8
Obatoclax (GX15-070) Size:2mg solid These results indicate CI-1040 exertsObatoclax, also known as GX 015 070, a synthetic small molecule inhibitor of the bcl 2 family of proteins with potential pro apoptotic and antineoplastic activities. Obatoclax binds to members of the Bcl 2 protein family, preventing the binding of these anti apoptotic proteins to the pro apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl 2 overexpressing cells. The Bcl 2 family of proteins (bcl 2, bcl xl,