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and it is a powerful inhibitor of kinases other than CK2
also called doxorubicin
Formula: C20H25ClN2O
In MIN6 insulinoma cells
norgestrienone
RI-1 - CAS# 415713-60-9 n (1-7) and it is a powerfulRI 1 is an irreversible inhibitor of RAD51 (IC50s = 5 30 M), a protein that is central to homologous recombination during DNA repair and is overexpressed in a wide range of human cancer cell types. RI 1 specifically reduces gene conversion in human cells while stimulating single strand annealing. RI 1 binds covalently to the surface of RAD51 protein at cysteine 319 that likely destabilizes an interface used by RAD51 monomers to oligomerize into
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