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Smiles: O=S1(=O)N=C(NC2=CC=CC=C2N2CCCC2)C2=CC=CC=C12
68(4):1162-9
InChiKey: AZCGOTUYEPXHMJ-PSVHYZMASA-N
and acute toxicity in vivo
1007/s40265-019-01210-0
PKI-179 hydrochloride - CAS# 1463510-35-1 Catalog No.:M16656-C Smiles: O=S1(=O)N=C(NC2=CC=CC=C2N2CCCC2)C2=CC=CC=C12PKI 179 hydrochloride is a potent and orally active dual PI3K mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0. 42 nM for PI3K , PI3K , PI3K , PI3K and mTOR, respectively. PKI 179 hydrochloride also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI 179 hydrochloride shows anti tumor activity in vivo. Product information CAS Number: 1463510 35 1 Molecular Weight: 525. 00 Formula: C25H29ClN8O3
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