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reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease
J Antibiot (Tokyo)
1051/medsci/20132910007
CAS Number: 179474-81-8
It achieves an IC50 value of 1
Eltrombopag (Olamine) Size:Solid 2 mg reduces sickling and prolongs RBCEltrombopag is a small molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. Eltrombopag was
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