GV-58 60427 InChi: InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H

InChi: InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H

1007/s40265-017-0816-z

InChi: InChI=1S/C27H24FN3O/c28-24-13-11-22(12-14-24)26-27(23-15-17-29-18-16-23)31(25(30-26)10-4-5-20-32)19-6-9-21-7-2-1-3-8-21/h1-3

Chemical Name: (S)-3-(1H-indol-3-yl)-N-((1-(4-methoxyphenyl)cyclohexyl)methyl)-2-(3-(4-nitrophenyl)ureido)propanamide

and Sirtuin2

GV-58 60427 InChi: InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6HGV 58 is a potent, selective N and P Q type Ca2+ channels agonist with EC50 of 7. 21 8. 81 uM for N type P Q type Ca2+ channel; 20 fold less potent CDK inhibitor activity. IC50 value: 7. 21 8. 81 uM (N type P Q type Ca2+ channel) Target: Ca2+ channel agonistIn comparison with the parent molecule, (R) roscovitine, GV 58 has a 20 fold less potent cyclin dependent kinase antagonist effect, a 3 to 4 fold more potent Ca2+ channel agonist effect, and 4 fold