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iHCK-37 (3-9 μM
10(32):3013-3026
2) Ca2+ channels in a voltage-dependent fashion (IC50=2 μM) and attenuates low voltage-activated (LVA) currents in rat DRG neurons (IC50=8 μM)
however cytokine release is fully blocked from T-cells in a mouse preparation
22(6):755-63
IACS-8968 R-enantiomer xylic acid) iHCK-37 (3-9 μMIACS 8968 (R enantiomer) is the R enantiomer of IACS 8968. IACS 8968 is a dual IDO and TDO inhibitor, with pIC50s of 6. 43 for IDO and <5 for TDO, respectively. Product information CAS Number: 2239305 67 8 Molecular Weight: 381. 35 Formula: C17H18F3N5O2 Chemical Name: (5R) 6,6 dimethyl 8 [7 (trifluoromethyl)imidazo[1,5 a]pyridin 5 yl] 1,3,8 triazaspiro[4. 5]decane 2,4 dione Smiles: CC1(C)CN(CC[C@]21NC(=O)NC2=O)C1=CC(=CC2=CN=CN21)C(F)(F)F InChiKey:
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